Sean Lamont is the only player to return to the starting team that overcame Italy 16-12 in Turin last weekend.
The 95-times capped Glasgow Warriors wing starts a third straight summer Test, having been brought back into the squad as a replacement for Tommy Seymour who has back pain.
Lock Grant Gilchrist would have also been set for his third start this summer had sickness not ruled him out of last weekend's game on the morning of the match, however the Alloa man is back in the boiler-house alongside Jonny Gray to reunite a combination that first, and last, took the field together on the 2014 summer tour.
In the front-row, Edinburgh Rugby trio Alasdair Dickinson, Ross Ford and Willem Nel start the match after their impressive replacement appearance against Italy, with a powerful and dynamic back-row trio of John Barclay, David Denton and Ryan Wilson completing the pack.
Ford's appearance will see him overtake the appearance record for a Scotland forward that he shares with former lock Scott Murray, when he makes his 88th appearance for his country this Saturday.
In the back-three, mainstay Lamont is joined by full-back Stuart Hogg and Harlequins' wing Tim Visser.
Glasgow Warriors' Peter Horne starts alongside teammate Mark Bennett in midfield, while Finn Russell and captain Greig Laidlaw will look to orchestrate proceedings at half-back.
Scotland Head Coach Vern Cotter said: "It's a good indication of our growing quality and depth that we're able to pitch another quite different, yet talented, side into battle this Saturday.
"Many of these players have worked hard all summer long and have had to wait patiently on the sidelines for this opportunity.
"They're keen to pull on the jersey, get out there, and put in a strong performance as part of a successful Scotland team.”
Reflecting on Saturday's record crowd for a Scottish summer Test match, he added: "The players and coaches are always very grateful for the support we get at BT Murrayfield, so the news of Saturday's record crowd gave everyone a nice lift at the start of this week.
"Our job is to go out there and be accurate in our application and perform to our ability. Do that and we'll be on the right track to delivering a performance for which the Scottish people can be proud, in what is our last home appearance before the Rugby World Cup.”
Scotland team: Stuart Hogg; Sean Lamont, Mark Bennett, Peter Horne, (all Glasgow), Tim Visser (Harlequins); Finn Russell (Glasgow), Greig Laidlaw capt (Gloucester); Alasdair Dickinson, Ross Ford, Willem Nel, Grant Gilchrist (all Edinburgh).
Jonny Gray, Ryan Wilson (both Glasgow), John Barclay (Scarlets), David Denton (Edinburgh). Substitutes
Stuart McInally (Edinburgh), Gordon Reid, Jon Welsh, Robert Harley (all Glasgow), Blair Cowan (London Irish), Henry Pyrgos (Glasgow ), Ruaridh Jackson (Wasps), Matt Scott (Edinburgh)
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